Unnatural enantiomers of 5-azacytidine analogues: syntheses and enzymatic properties.
Gaubert G, Mathé C, Imbach J, Eriksson S, Vincenzetti S, Salvatori D, Vita A, Maury G.
Gaubert G, et al.
Eur J Med Chem. 2000 Nov;35(11):1011-9. doi: 10.1016/s0223-5234(00)01184-3.
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PMID: 11137229
Although 2'-deoxy-beta-D-5-azacytidine (Decitabine) and beta-D-5-azacytidine display potent antileukemic properties, their therapeutic use is hampered by their sensitivity to nucleophiles and to deamination catalysed by cytidine deaminase. As shown earlier [Shafiee M …
Although 2'-deoxy-beta-D-5-azacytidine (Decitabine) and beta-D-5-azacytidine display potent antileukemic properties, their therapeutic use i …